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1. 1. Numerical Algorithms for Optimization Problems in Genetical Analysis

   Författare :Kateryna Mishchenko; Sverker Holmgren; Dmitrii Silvestrov; Lars Rönnegård; Ann-Charlotte Berglund Sonnhammer; Mälardalens högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantitative Trait Loci QTL ; restricted maximum likelihood REML ; variance components; average information AI matrix; Local optimization; Quasi-Newton method; Active Set method; Hessian approximation; BFGS update; Applied mathematics; Tillämpad matematik; Matematik tillämpad matematik;

   Sammanfattning : The focus of this thesis is on numerical algorithms for efficient solution of QTL analysis problem in genetics.Firstly, we consider QTL mapping problems where a standard least-squares model is used for computing the model fit. LÄS MER