Sökning: "aspartate"

Visar resultat 21 - 25 av 113 avhandlingar innehållade ordet aspartate.

1. 21. Counter-current distribution of interacting molecules : simulation of distribution behaviour and application to protein-protein interactions

   Författare :Lars Backman; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Associations of biological macromolecules with other macromolecules, with larger assemblies of macromolecules and with themselves are widely encountered phenomena. In principle, these interactions can be studied with any method able to differentiate between free molecules and complexes formed. LÄS MER

3. 22. Studies on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

   Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER

4. 23. Structural studies of saccharopine reductase and purple acid phosphatase

   Författare :Eva Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Lysine is synthesised in two different ways in living organisms, either by the diaminopimelate pathway or the [alpha]-aminoadipate pathway. These routes belong to the aspartate and the glutamate family of amino acid biosynthesis, respectively. LÄS MER

5. 24. The effect of alpha-HGA on HIV-1 replication

   Författare :Masoud Youssefi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; p24; capsid formation; alpha-HGA; antiretroviral; uptake;

   Sammanfattning : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. LÄS MER

7. 25. Monitoring of extracellular substances after spontaneous and experimental subarachnoid hemorrhage

   Författare :Magnus Runnerstam; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subarachnoid hemorrhage; Microdialysis; Amino acids; GFAP; Iron; Apoptosis;

   Sammanfattning : Even though survival is considerably enhanced after surgical treatment of an aneurysmal subarachnoid hemorrhage (SAH), there is a critical period, which keeps the patient in intensive care for days or even weeks. Complications, such as vasospasm, ischemia and brain edema ultimately lead to further brain damage. LÄS MER