Sökning: "aspartate"

Visar resultat 16 - 20 av 113 avhandlingar innehållade ordet aspartate.

  1. 16. Molecular mechanisms of synaptic transmission and plasticity in spinal sensory pathways

    Författare :Max Larsson; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; electron microscopy; synaptic plasticity; synapse; pain; spinal cord; hyperalgesia; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : An intense, potentially tissue-damaging (noxious) stimulus may lead to enhanced pain sensation of subsequent noxious stimuli (hyperalgesia) and to the perceiving of innocuous stimuli as painful (allodynia). This is thought to result to a large extent from strengthening of synapses established by primary afferent fibers onto spinal cord dorsal horn neurons. LÄS MER

  3. 17. Mitochondrial differentiation during the early development of the amphibian embryo

    Författare :Lennart Nelson; Barbara Cannon; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amphibia; Xenopus laevis; Ambystoma mexicanum; mitochondria; differentiation; enzymes; carriers; oxidation; development; Zoophysiology; zoofysiologi;

    Sammanfattning : Mitochondria from Xenopus laevis and Ambystoma mexica- num embryos between fertilization and the beginning of feeding were studied: the former with respect to metabolic behaviour, enzyme pattern and carrier activity, and the latter with respect to morphological parameters.The metabolic behaviour of mitochondria was studied by assessing the rates of oxygen uptake in presence of various substrates. LÄS MER

  4. 18. Structural Insights at Sub-Ångstrom, Medium and Low Resolution: Crystallization of Trypsin, Bacterioferritin, Photosynthetic Reaction Center, and Photosynthetic Core Complex

    Författare :Weixiao Yuan Wahlgren; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein crystallization; cubic phase; sponge phase; bicelle; trypsin; bacterioferritin; reaction center; core complex; photosynthesis;

    Sammanfattning : The catalytic action of serine proteases depends on the interplay of a nucleophile, a general base and a general acid. The catalytic triad is composed of serine, histidine and aspartate residues. The serine acts as a nucleophile while the histidine plays a dual role as the general base or acid at different steps of the reaction. LÄS MER

  5. 19. A star is born : development of NT* as a new biotechnological tool based on the mechanism of pH dependent dimerization of the spidroin N-terminal domain

    Författare :Médoune Sarr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Proteins are widely used in research and in the pharmaceutical industry but the production of recombinant protein can be tedious, costly and time-consuming due to unwanted aggregation. Strategies to circumvent aggregation, e.g. the use of solubility tags, must be evaluated experimentally and successful results are not always obtained. LÄS MER

  7. 20. The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity

    Författare :Shamim Dadvar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, this disruption causes a systemic low-grade inflammation and impairs energy homeostasis. LÄS MER