Sökning: "arachidonic acid metabolites"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden arachidonic acid metabolites.

  1. 1. Thrombin-induced pulmonary injury in the rat : role of neutrophil elastase and arachidonic acid metabolites

    Författare :Chul Min Ahn; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Identification of arachidonic acid metabolites formed through the 15-lipoxygenase-1 pathway

    Författare :Åsa Brunnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The polyunsaturated fatty acid arachidonic acid is the precursor of many biologically active lipid mediators. This thesis is focused on the arachidonic acid metabolites formed through the 15-lipoxygenase-1 (15-LO-1) pathway. LÄS MER

  4. 3. OX1 Orexin Receptor Signalling to Phospholipases

    Författare :Marie Ekholm; Jyrki Kukkonen; Graeme Milligan; Uppsala universitet; []
    Nyckelord :orexin; phospholipase; Calcium; cell signalling; G protein coupled receptor; ERK; live-cell imaging; arachidonic acid; diacylglycerol;

    Sammanfattning : The neuropeptides orexin-A and orexin-B were discovered in 1998 and were first described as regulators of feeding behaviour. Later research has shown that they have an important role in the regulation of sleep. Two G protein-coupled receptors, OX1 and OX2 orexin receptors, mediate the cellular responses to orexins. LÄS MER

  5. 4. Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21

    Författare :Johan Bylund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids. LÄS MER

  7. 5. Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells

    Författare :Stina Feltenmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells. The first part of the thesis (papers I & II) describes the expression of genes involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). LÄS MER