Sökning: "apoE"

Visar resultat 1 - 5 av 165 avhandlingar innehållade ordet apoE.

  1. 1. Odor identification in aging and dementia : Influences of cognition and the ApoE gene

    Författare :Jonas Olofsson; Steven Nordin; Maria Larsson; Richard Doty; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Aging; olfaction; identification; dementia; Alzheimer; genetics; ApoE; population based; cognition; demographics; Psychology; Psykologi;

    Sammanfattning : Olfactory function is impaired in aging and dementia. The general aim of this thesis was to identify variables that predict olfactory function and dysfunction (assessed with an odor identification test) in middle-aged and elderly adults. LÄS MER

  3. 2. Biomarkers for Alzheimer's disease and the APOE polymorphism

    Författare :Ronald Lautner; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER

  4. 3. Polyphenols in Swedish berries and pulses : Characterization and in vivo effects of fractions from lingonberries and brown beans in an Apoe-/- mouse model

    Författare :Jiyun Liu; Cornelia Witthöft; Anne-Maria Pajari; Linnéuniversitetet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; lingonberry; brown bean; flavonoids; phenolic acids; dietary fiber; HPLC-UV MS; atherosclerotic plaque; plasma lipid; gut microbiota; short-chain fatty acids; trimethylamine N-oxide; Apoe- - mice; lingon; bruna bönor; flavonoider; fenolsyror; kostfiber; HPLCUV MS; aterosklerotisk plaketter; plasmalipid; tarm-mikrobiota; kortkedjiga fettsyror; trimetylamin N-oxid; Apoe- - möss; Livsmedelsvetenskap; Food Science;

    Sammanfattning : Consumption of berries and pulses can protect against atherosclerosis and other metabolic diseases, by modulating plasma lipid profile, gut microbiota, and microbiota-dependent metabolites. These nutritional benefits are often attributed to high content of polyphenols (flavonoids and phenolic acids) and dietary fiber. LÄS MER

  5. 4. Cognitive change in aging: A life span perspective of gender and individual differences in APOE genotype

    Författare :Marcus Praetorius; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; cognitive performance; late life; APOE; gender; time to death;

    Sammanfattning : Degree of licentiate in Psychology Abstract Praetorius, M. (2011). Cognitive change in aging: A life span p erspective of gender and individual differences in APOE genotype. LÄS MER

  7. 5. Genes to remember : imaging genetics of hippocampus-based memory functions

    Författare :Karolina Kauppi; Lars Nyberg; Jonas Persson; Guillén Fernández; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Imaging genetics; fMRI; Episodic memory; SNP; KIBRA; BDNF; APOE; Hippocampus; Parahippocampus;

    Sammanfattning : In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. LÄS MER