Sökning: "apoE- - mice"

Visar resultat 1 - 5 av 58 avhandlingar innehållade orden apoE- - mice.

  1. 1. Polyphenols in Swedish berries and pulses : Characterization and in vivo effects of fractions from lingonberries and brown beans in an Apoe-/- mouse model

    Författare :Jiyun Liu; Cornelia Witthöft; Anne-Maria Pajari; Linnéuniversitetet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; lingonberry; brown bean; flavonoids; phenolic acids; dietary fiber; HPLC-UV MS; atherosclerotic plaque; plasma lipid; gut microbiota; short-chain fatty acids; trimethylamine N-oxide; Apoe- - mice; lingon; bruna bönor; flavonoider; fenolsyror; kostfiber; HPLCUV MS; aterosklerotisk plaketter; plasmalipid; tarm-mikrobiota; kortkedjiga fettsyror; trimetylamin N-oxid; Apoe- - möss; Livsmedelsvetenskap; Food Science;

    Sammanfattning : Consumption of berries and pulses can protect against atherosclerosis and other metabolic diseases, by modulating plasma lipid profile, gut microbiota, and microbiota-dependent metabolites. These nutritional benefits are often attributed to high content of polyphenols (flavonoids and phenolic acids) and dietary fiber. LÄS MER

  3. 2. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

    Författare :Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

    Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER

  4. 3. Cardiovascular effects of growth hormone. Studies in genetically engineered mice

    Författare :Irene Andersson; Göteborgs universitet; []
    Nyckelord :acromegaly; autonomic nervous system; cardiovascular disease; cardiac function; vascular function; growth hormone; heart rate variability; hypertension; insulin-like growth factor-1; transgenic mice;

    Sammanfattning : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. LÄS MER

  5. 4. Genetic Studies of Alzheimer's Disease

    Författare :Elin Blom; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Jan Hillert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Linkage; Affected sib-pairs; APOE; APP duplication; 10q21; 19q13; Wnt signaling; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi;

    Sammanfattning : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. LÄS MER

  7. 5. Novel host defence mechanisms during bacterial infections

    Författare :Malin Elvén; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ApoE; Complement System; TFPI-2; Antimicrobial peptides; AMP; Immunolgobulins; endotoxins; Staphylococcus aureus; Pseudomonas aeruginosa; Escheria coli;

    Sammanfattning : The immune system has evolved through thousands of years and its architecture has challenged the medical field since the first hieroglyphs and will likely continue do so. With our co-evolution with millions of other species, the complexity to treat infectious diseases has been a race in increasing speed ever since. LÄS MER