Sökning: "antiviral protein"

Visar resultat 1 - 5 av 95 avhandlingar innehållade orden antiviral protein.

  1. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

    Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

  3. 2. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

    Författare :Koushikul Islam; Clas Ahlm; Magnus Evander; Anna K. Överby; Johan Neyts; Umeå universitet; []
    Nyckelord :Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

    Sammanfattning : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. LÄS MER

  4. 3. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms

    Författare :Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. LÄS MER

  5. 4. Diving into short linear motifs : Large-scale identification of endogenous and host-pathogen protein-protein interactions and further characterized by deep mutational scanning

    Författare :Caroline Benz; Ylva Ivarsson; Birthe B. Kragelund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein-protein interactions; short linear motif; endogenous interactions; host-pathogen; viral hijacking; deep mutational scanning; Biokemi; Biochemistry;

    Sammanfattning : Short linear motifs (SLiMs) are protein-protein interaction sites that play an essential role in distinct cellular processes. Those interactions are challenging to capture by common high-throughput methods. LÄS MER

  7. 5. The role of non-coding single-stranded oligonucleotides on Respiratory syncytial virus infection

    Författare :Sandra Axberg Pålsson; Anna-Lena Spetz; Annika Karlsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Respiratory syncytial virus RSV ; single-stranded oligonucleotide ssON ; small non-coding RNA sncRNA ; nucleolin; virus infection; antiviral; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Respiratory syncytial virus (RSV) is an enveloped RNA virus of the Pneumoviridae family. RSV is reported to infect host cells by receptor-mediated endocytosis, also called clathrin-dependent endocytosis. Many reports indicate that the virus utilizes the host receptor nucleolin for entry. LÄS MER