Sökning: "antisense"

Visar resultat 1 - 5 av 135 avhandlingar innehållade ordet antisense.

1. 1. Antisense technology and bone resorption

   Författare :Marie Suzanne Westberg; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antisense DNA; carbonic anhydrase II; vacuolar H -ATPase; bone resorption; ostoclast;

   Sammanfattning : .... LÄS MER

3. 2. Functional characterization of the small antisense RNA MicA in Escherichia coli

   Författare :Klas Ifeanyi Udekwu; Gerhart Wagner; Tony Romeo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small RNA; antisense; outer membrane; Hfq-dependence; RNase III; LuxS; Quorum sensing; Microbiology; Mikrobiologi; mikrobiologi; Microbiology;

   Sammanfattning : The Escherichia coli small RNA (sRNA) MicA was identified recently in a genomewide search for sRNAs. It is encoded between the genes gshA and luxS in E. coli and its close relatives. The function of sRNAs in bacteria is generally believed to be in maintenance of homeostasis via stress-induced modulation of gene expression. LÄS MER

4. 3. Making Sense of Antisense

   Författare :Johan Reimegård; Gerhart Wagner; Hanah Margalit; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sRNA; miRNA; RNA; target prediction; SOLiD siRNA; E.coli; D.discoideum; Biology; Biologi; Bioinformatics; Bioinformatik; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : RNA is a highly versatile molecule with functions that span from being a messenger in the transfer from DNA to protein, a catalytic molecule important for key processes in the cell to a regulator of gene expression. The post-genomic era and the use of new techniques to sequence RNAs have dramatically increased the number of regulatory RNAs during the last decade. LÄS MER

5. 4. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

   Författare :Oommen P. Varghese; Lars Engman; Jacek Stawinski; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chemically modified oligonucleotides; azetidine; aza-ENA-T; cyanomethylene locked; free energy of activation; diaxial interactions; chair conformation; stable duplex; human serum; snake venom phosphodiesterase; antisense agents; RNase H; Organisk kemi; Chemistry; Kemi;

   Sammanfattning : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. LÄS MER

7. 5. Dissecting the photosystem II light-harvesting antenna

   Författare :Jenny Andersson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant physiology; antisense; Arabidopsis thaliana; chlorophyll; carotenoid; feedback de-excitation; fitness; LHC; NPQ; photosynthesis; state transitions; xanthophyll; Växtfysiologi; Plant physiology; Växtfysiologi; Physiological Botany; fysiologisk botanik;

   Sammanfattning : In photosynthesis, sunlight is converted into chemical energy that is stored mainly as carbohydrates and supplies basically all life on Earth with energy.In order to efficiently absorb the light energy, plants have developed the outer light harvesting antenna, which is composed of ten different protein subunits (LHC) that bind chlorophyll a and b as well as different carotenoids. LÄS MER