Sökning: "antineoplastic agents"

Hittade 5 avhandlingar innehållade orden antineoplastic agents.

  1. 1. Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs

    Författare :Anna Nyhlén; Sektion III; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; neutropenic; antineoplastic agents; pharmacokinetics; pharmacodynamics; PAE; interactions; synergy; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; mykologi; virologi;

    Sammanfattning : The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on the intestinal microflora. LÄS MER

  3. 2. Cellular toxicity of quinones : Redox- and addition chemistry

    Författare :Karin Öllinger; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Quinoid compounds are widely occurring in nature. They have cytotoxic properties and they are also used as antineoplastic agents. The cytotoxic properties can be explained by the ability of quinones to generate active oxygen species by redox cycling, by addition to cellular nucleophiles, and by inhibition of DNA transcription. LÄS MER

  4. 3. Polyamine analogues inhibit neuroblastoma cell growth

    Författare :Erika Söderstjerna; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

    Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER

  5. 4. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Författare :Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. LÄS MER

  7. 5. Aetiology and infection susceptibility in neutropaenic patients

    Författare :Michelle Wong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Increasingly intensive antineoplastic regimes have been effective in the treatment for haematological malignancies, but as effective as it is in limiting neoplasm of the malignant cells, bystander damage occurs equally to cells of the immune system and epithelial cells of the mucosa. Infectious complications following chemotherapy reflect this situation. LÄS MER