Sökning: "antidote"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet antidote.
1. Early assessment of efficacy and safety of novel anticoagulants as exemplified by direct thrombin inhibitors. Non-clinical pharmacodynamic studies in vitro and in vivo
Sammanfattning : The drawbacks of today's anticoagulants are parenteral use (heparins), a narrow interval between efficacy and bleeding, and the high variability of effect with a consequent need for frequent monitoring (coumarins). The aim of the current studies was to evaluate properties important for efficacy and safety of novel anticoagulants, as exemplified by direct thrombin inhibitors, with non-clinical methods. LÄS MER
2. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase
Sammanfattning : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. LÄS MER
3. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase
Sammanfattning : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. LÄS MER
4. Flotation-REST (Restricted Environmental Stimulation Technique) in the age of anxiety : Exploring the role and treatment applications of sensory isolation in the modern world
Sammanfattning : Anxiety and the use of Complementary and Alternative Medicine (CAM), such as flotation-REST, have increased markedly during the last decades. Anxiety is reportedly a prevalent incentive for the use of CAMs, despite the present low state of knowledge about their safety and efficacy. LÄS MER
5. Management of hemorrhagic complications associated with antithrombotic therapy
Sammanfattning : Anticoagulants are used for the prevention and treatment of arterial and venous thromboembolism. Such therapy is always associated with an increased risk of bleeding. Intracranial hemorrhage is the most serious form of anticoagulantsrelated bleeding and caries a high mortality rate. LÄS MER