Sökning: "anti-viral treatment"

Visar resultat 6 - 10 av 23 avhandlingar innehållade orden anti-viral treatment.

  1. 6. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets : Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

    Författare :Jimmy Lindberg; Torsten Unge; Alexander Wlodawer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. LÄS MER

  3. 7. Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet

    Författare :Alexandra Svensson; Göteborgs universitet; []
    Nyckelord :HSV-2; T-bet; Substance P; Neurokinin 1; IFN-alfa beta signaling; Polymorphisms;

    Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans. The infection gives rise to a wide range of symptoms, ranging from severe and painful recurrent episodes of genital herpes to silent infection. LÄS MER

  4. 8. New aspects of allergic mechanisms and innate immunity in asthma. Alarmins as upstream mediators of asthma inflammation

    Författare :Sangeetha Ramu; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Aeroallergens; Airway inflammation; Bronchial epithelial cells; Bronchial smooth muscle cells; Metabolic DAMPs; Proteases; Allergen immunotherapy; Mast cells; Viral infections; innate immunity;

    Sammanfattning : Asthma is a chronic inflammatory lung disease affecting over 300 million individuals worldwide. Both respiratory viral infections and aeroallergens have been identified as important risk factors for asthma. LÄS MER

  5. 9. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity

    Författare :Aleksandra Dondalska; Anna-Lena Spetz; Jenny Hallgren Martinsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; single-stranded oligonucleotides; Toll-like receptors; influenza; respiratory syncytial virus; dendritic cell; mast cell; virus infection; inflammation; itch; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. LÄS MER

  7. 10. Elucidating the role of DNA damage and human cytomegalovirus in medulloblastoma and glioblastoma

    Författare :Jiri Bartek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The most common primary malignant brain tumor in children is Medulloblastoma, while Glioblastoma is the most common in adults. Treatment for both include some combination of surgery, radiation therapy, and chemotherapy. LÄS MER