Sökning: "antennapedia homeodomain"

Hittade 3 avhandlingar innehållade orden antennapedia homeodomain.

  1. 1. Interactions of the Cell-Penetrating Peptide Penetratin with Model Membranes and Live Cells

    Författare :Daniel Persson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antisense; antennapedia homeodomain; delivery vector; cell-penetrating peptide; protein transduction; uptake; membrane translocation; penetratin; confocal microscopy; vesicle;

    Sammanfattning : The delivery of large, hydrophilic molecules, such as proteins and oligonucleotides, to the cytoplasm and nucleus of cells is problematic due to their generally low plasma membrane permeability. With the identification of a number of cell-penetrating peptides, capable of mediating non-endocytotic, intracellular delivery of macromolecular cargos, this obstacle now seems surmountable. LÄS MER

  3. 2. Studies of the interaction of penetratin with phospholipid vesicles

    Författare :Per Thoren; Daniel Persson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane translocation; vesicle aggregation; cell-penetrating peptides; cellular uptake; Antennapedia homeodomain; circular dichroism; membrane binding; penetratin;

    Sammanfattning : .... LÄS MER

  4. 3. Cell-penetrating peptides in model membrane systems : Interaction, structure induction and membrane effects

    Författare :Mazin Magzoub; Astrid Gräslund; Steven Dowdy; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik;

    Sammanfattning : Despite continuing advances in the development of macromolecules, including peptides, proteins, and oligonucleotides, for therapeutic purposes, the successful application of these hydrophilic molecules has so far been hampered by their inability to efficiently traverse the plasma membrane. The discovery of a class of peptides (cell-penetrating peptides, CPPs) with the ability to mediate the non-invasive and efficient import of a whole host of cargoes, both in vitro and in vivo, has provided a new means by which the problem associated with cellular delivery can be circumvented. LÄS MER