Sökning: "animal model"

Visar resultat 11 - 15 av 1018 avhandlingar innehållade orden animal model.

  1. 11. Exploring Brain Gene Expression i Animal Models of Behaviour

    Författare :Julia Lindberg; Elena Jazin; Peter Saetre; Jonathan Flint; Uppsala universitet; []
    Nyckelord :Biology; behavioural genetics; gene expression; brain; microarray analysis; domestication; animal model; haem; Canis familiaris; Vulpes vulpes; Mus musculus; Biologi;

    Sammanfattning : The genetic basis for behavioural traits is largely unknown. The overall aim of this thesis was to find genes with importance for behavioural traits related to fear and anxiety. Microarray analysis was used to screen expression profiles of brain regions important for emotional behaviour in dogs, wolves, foxes and mice. LÄS MER

  3. 12. Gene therapy in a new model of delayed wound healing

    Författare :Patrik Velander; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Gene therapy; Diabetes; Animal model; EGF;

    Sammanfattning : Diabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. LÄS MER

  4. 13. Artificial Neural Networks (ANN) in the Assessment of Respiratory Mechanics

    Författare :Gaetano Perchiazzi; Göran Hedenstierna; Björn Jonson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; artificial neural networks; respiratory system compliance; respiratory system resistance; respiratory system time constant; intrinsic positive end expiratory pressure; PEEPi; animal model; acute lung injury; oleic acid; Otis model; Fysiologi; Physiology; Fysiologi;

    Sammanfattning : The aim of this thesis was to test the capability of Artificial Neural Networks (ANN) to estimate respiratory mechanics during mechanical ventilation (MV). ANNs are universal function approximators and can extract information from complex signals. LÄS MER

  5. 14. Uridine, 4-thiouridine and isomaltitol in an asthma-like model : Anti-inflammatory and modulating effects

    Författare :Chamilly Evaldsson; Srinivas Uppugunduri; Margareta Linden; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Uridine; asthma; 4-thiouridine; isomaltitol; isomalt; inflammation; eosinophilia; Sephadex; animal model; rat; Pharmaceutical pharmacology; Farmaceutisk farmakologi; MEDICINE; MEDICIN; Lung diseases; Lungsjukdomar;

    Sammanfattning : In chronic inflammatory diseases like asthma or rheumatoid arthritis, erroneous and exaggerated accumulation of leukocytes in a tissue inadvertently causes the body harm. Several efficient anti-inflammatory drugs exist, for example corticosteroids and cyclo-oxygenase inhibitors. LÄS MER

  7. 15. Radiobiological studies with low energy ionizing radiation - dosimetric aspects

    Författare :Gustav Grafström; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; low energy; Radiobiology; dosimetry; cell model; Radiofarmaceutisk teknik; Radiopharmaceutical technology; radiobiologi; Nukleärmedicin; radiobiology; Nuclear medicine; animal model;

    Sammanfattning : Background: During the last 20 years both in vitro and in vivo models have been developed for studies of the cell killing characteristics of low energy electrons, e.g. Auger electrons. This thesis deals with radiobiological effects of radiation from indium isotopes in V79 cells in vitro (Paper I-III) and the rat testis in vivo (Paper IVV). LÄS MER