Sökning: "aminocarbonylation"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet aminocarbonylation.

1. 1. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

   Författare :Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
   Nyckelord :Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

   Sammanfattning : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. LÄS MER

3. 2. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

   Författare :Johan Wannberg; Anders Hallberg; David C. Rees; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Sammanfattning : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. LÄS MER

4. 3. Development of HIV-1 Protease Inhibitors and Palladium-Catalyzed Synthesis of Aryl Ketones and N-Allylbenzamides

   Författare :Linda Axelsson; Mats Larhed; Anders Karlén; Luke Odell; Morten Grötli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; palladium; aminocarbonylation; aryl ketones; decarboxylation; HIV; protease inhibitor; tertiary alcohol; macrocycles; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The use of palladium-catalyzed reactions to introduce new carbon-carbon bonds is a fundamental synthetic strategy that has been widely embraced due to its high chemo- and regioselectivity and functional group tolerance. In this context, Pd(0)-catalyzed aminocarbonylations using Mo(CO)6 instead of toxic and gaseous CO and with allylamine as the nucleophile were investigated. LÄS MER

5. 4. Design and Synthesis of Novel Glutamine Synthetase Inhibitors and Development of Palladium(0)-Catalyzed Aminocarbonylation

   Författare :Olof Lagerlund; Mats Larhed; Anders Karlén; Anders Hallberg; Michael Begtrup; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

   Sammanfattning : Tuberculosis (TB) is a major infectious disease, killing about 2 million people annually throughout the world. Today's TB treatment is a lengthy procedure involving a combination of antibiotics. No new TB drug has been introduced onto the market in the past 40 years, and the emergence of multi- and extensively drug-resistant TB calls for new drugs. LÄS MER

7. 5. Catalytic Formation of Amides

   Författare :Fredrik Tinnis; Hans Adolfsson; Jonathan Williams; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organisk kemi; Organic Chemistry;

   Sammanfattning : The amide functionality is a highly important chemical bond, found in a great number of synthetic products such as pharmaceuticals, polymers and agrochemicals. The focus of this thesis has been directed towards efficient, mild and environmentally friendly methods for amide formations. LÄS MER