Sökning: "all-trans Retinoic acid"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden all-trans Retinoic acid.

  1. 1. Retinoid metabolism and signalling in vascular smooth muscle cells

    Författare :Pauline Ocaya; Allan Sirsjö; Andreas C. Gidlöf; William S. Blaner; Örebro universitet; []
    Nyckelord :all-trans Retinol; all-trans Retinoic acid; retinoid metabolism; proliferation; Vascular smooth muscle cells; CYP26; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Smooth muscle cells (SMCs) play a major role in cardiovascular diseases. In advanced atherosclerosis, blood flow is impaired due to reduced luminal diameter. Percutaneous vascular interventions, including balloon angioplasty and stent-application are commonly used for the re-establishment of luminal size and improvement of tissue perfusion. LÄS MER

  3. 2. The informational value and usefulness of serum retinoid measurements. Studies on biological variation, including infancy and pregnancy, and influence of fasting, antiepileptic drugs and ethanol

    Författare :Maria Berggren Söderlund; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; vitamin A deficiency; teratogenicity; ethanol; antiepileptic drugs; caloric restriction; infant; pregnant; biological variation; 13-cis retinoic acid; all-trans retinoic acid; Vitamin A; retinol;

    Sammanfattning : The aims of these studies were to evaluate retinoid measurements, more specifically the performance of all-trans and 13-cis retinoic acids methods in clinical experimental settings and to evaluate the informational value of these measurements in relation to S-Retinol. Biological and analytical variations for retinoids were evaluated for healthy subjects. LÄS MER

  4. 3. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Författare :Astrid Bengtsson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Sammanfattning : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. LÄS MER

  5. 4. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

  7. 5. Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis

    Författare :Elizabeth Pavez Loriè; Anders Vahlquist; Hans Törmä; Marie Virtanen; Helen Håkansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP; CYP26; retinoids; vitamin A; RAMBA; metabolism; keratinocyte; epidermis; retinoid regulated genes; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Retinoic Acid Metabolism Blocking Agents (RAMBAs) increase the endogenous levels of all-trans retinoic acid (RA) by inhibiting CYP26 enzymes. Thus they are believed to mimic the effects of retinoid treatment. Their mechanism of action and effects on vitamin A metabolism in keratinocytes are however uncertain. LÄS MER