Sökning: "activin"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet activin.

  1. 1. Neuronal Development in the Embryonic Retina : Focus on the Characterization, Generation and Development of Horizontal Cell Subtypes

    Författare :Per-Henrik Edqvist; Finn Hallböök; Steven McLoon; Uppsala universitet; []
    Nyckelord :Neurosciences; Activin; Chick; Follistatin; Interneuron; Isl1; Lim1; Migration; Neurogenesis; Prox1; Transcription factor; Neurovetenskap;

    Sammanfattning : Horizontal cells are retinal interneurons that modulate the output from photoreceptors. Two horizontal cell (HC) subtypes are commonly identified in the vertebrate retina: axon-bearing and axon-less HCs. LÄS MER

  3. 2. Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells

    Författare :Åsa Franzén; Paschalis Sideras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; activin; BMP; cadherin; carcinoma; cell cycle arrest; dedifferentiation; EGF; growth inhibition; invasion; Smad; TGF-β; thyroid; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells. LÄS MER

  4. 3. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

    Författare :Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
    Nyckelord :Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

    Sammanfattning : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. LÄS MER

  5. 4. Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm

    Författare :Karin Norrman; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; diabetes; pancreas; definitive endoderm; foregut endoderm; pancreatic endoderm; constitutive promoter; ACTB; EF1alpha; CMV; PGK; UbC;

    Sammanfattning : Abstract More than 300 million people are suffering from diabetes worldwide and the numbers of diabetic patients are increasing. Today´s treatments mainly rely on daily insulin injections. This help people to control blood glucose levels but still many patients suffer from the many complications associated with diabetes. LÄS MER

  7. 5. Human ovarian follicle recruitment : an in vitro approach

    Författare :Jennifer E Scott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Following the first reports of successful cryopreservation of human ovarian tissue, the freezing and banking of such tissue has become common practice worldwide for the preservation of fertility. Patients include those at risk of premature ovarian failure, women and girls with Turner's syndrome, and cancer patients for whom radiation or cytotoxic treatments are likely to destroy their reproductive potential. LÄS MER