Sökning: "WKY"

Hittade 4 avhandlingar innehållade ordet WKY.

  1. 1. Deviant sexual behavior, hormones and sex-chromosomal relationship : A study in the spontaneously hypertensive rat (SHR)

    Författare :Anders Wall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; SHR; WKY; Rat; Copulatory performance; Deviant sexual behavior; Neuroendocrine mechanisms; Neonatal; Farmakologi; Pharmacological research; Farmakologisk forskning; Neurology; neurologi;

    Sammanfattning : The general aim of the present thesis was to gain insight into some biological factors that influencedeviant sexual performance. Two inbred strains selectively bred (hypertension) from the same Wistarrat colony were used: the spontaneously hypertensive rat (SHR) and its normotensive progenitor theWistar Kyoto rat (WKY). LÄS MER

  3. 2. Endothelium-derived substances and regional hemodynamics in experimental hypertension

    Författare :Sven-Olof Granstam; Uppsala universitet; []
    Nyckelord :Medical sciences; nitric oxide; endothelin; hypertension; rats; SHR; hemodynamics; blood pressure; blood flow; acetylcholine; carvedilol; microsphere method; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The spontaneously hypertensive rat (SHR), a model for experimental hypertension, is considered to have similarities with essential hypertension in humans. Differences between SHR and normotensive Wistar Kyoto rats (WKY) in the vascular response to endothelial-derived substances such as nitric oxide (NO) have been intensively studied in vitro. LÄS MER

  4. 3. Reciprocal interactions of neuropeptide y and angiotensin II receptors with a2-adrenoceptors in the nucleus tractus solitarii of the rat

    Författare :Shao-Nian Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neuropeptide Y angiotensin II adrenaline noradrenaline; clonidinereceptor receptor-receptor interaction cardiovascular control immediate earlygene microinjection quantitative receptor autoradiographyimmunocytochemistry in situ hybridization ~ ;

    Sammanfattning : Neuropeptide Y (NPY), angiotensin II (Ang II) and adrenergic transmission lines in the nucleus tractus solitarii (NTS), the major relay nucleus involved in the cardiovascular reflex, play an important role in central cardiovascular control. The present work explored reciprocal interactions of NPY and Ang II receptor subtypes with a2-adrenoceptors in the NTS of the normotensive Sprague-Dawley rat (SD), the normotensive Wistar Kyoto rat (WKY) and the spontaneously hypertensive rat (SHR) by using a cardiovascular analysis, quantitative receptor autoradiography, immunocytochemistry and in situ hybridization techniques. LÄS MER

  5. 4. Cardiovascular dysfunction in obstructive sleep apnea

    Författare :Holger Kraiczi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstructive sleep apnea; blood pressure; cardiac size; left ventricular function; endothelium-dependent vasodilation; forearm vascular conductance; natriuretic peptides;

    Sammanfattning : This thesis addresses relationships between the presence or severity of obstructive sleep apnea (OSA) and blood pressure (BP) as well as other signs of cardiovascular dysfunction.In a cross-sectional investigation of a sleep laboratory cohort of 81 patients, a dose response relationship was observed between the number of apneas plus hypopneas per hour of sleep (apnea-hypopnea index, AHI; measured with polysomnography) and office systolic and diastolic BP (SBP and DBP), daytime ambulatory DBP as well as nighttime ambulatory SBP and DBP (all ambulatory measurements taken at 20-minute intervals). LÄS MER