Sökning: "VLPs"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet VLPs.

  1. 1. Polyomavirus infections in humans

    Författare :Annika Lundstig; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Polyomaviruses; tumour virology; BK virus; neuroblastoma; maternal infection; Real Time PCR; enzyme immunoassay; seroprevalence; JC virus; SV40; virus like particles VLPs ; seroepidemiology; biobank; mesothelioma tissues; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : The human polyomaviruses BKV and JCV are endemic and infect > 70% of population worldwide. Primary infections occur during childhood and are largely subclinical. Following primary infection, both viruses persist as latent infections in the kidneys and B lymphocytes. LÄS MER

  3. 2. Human Papillomavirus vaccination: Immunological and epidemiological studies

    Författare :Janka Ryding; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzyme-linked immunosorbent assay ELISA ; Human Papillomavirus HPV ; parallel line method PLL ; mathematical modeling; virus-like particles VLPs ; prevalence; serology;

    Sammanfattning : This thesis has evaluated the immunological- and epidemiological aspects of human papillomavirus transmission dynamics and its effect on circumcision. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope is defined by the monoclonal antibody H16.V5. LÄS MER

  4. 3. Type-specific human papillomavirus antibodies : detection, characterization and application in seroepidemiology

    Författare :Zhaohui Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antagonism; antibody; capsids; cervical carcinoma; CIN; epidemiology; HPV; isotype; neutralizing epitope; PCR; STDs; trends over time; VLPs;

    Sammanfattning : Background: Human Papillomavirus (HPV) is a sexually transmitted DNA virus that causes several human cancers, notably cervical and other anogenital cancers. The antibody response to this virus is of interest both because knowledge of the antigenic structures that induce protective immunity forms the basis for prophylactic vaccine development and because it forms the basis of seroepidemiology, the method of choice for studies of HPV infectivity, of HPV spread in populations and of cancer risks following HPV exposure. LÄS MER

  5. 4. Studies on polyomavirus virus-like particles : as vaccines and vectors for immune and gene therapy

    Författare :Karin Tegerstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Polyomavirus; virus-like particles; immunotherapy; Her2 and dendritic cells;

    Sammanfattning : Virus-like particles (VLPs) are similar to natural virus particles except that they lack viral genes. They have a similar cellular uptake to the natural virus from which they are derived but are non-infectious and can therefore not reproduce themselves. LÄS MER

  7. 5. Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion

    Författare :Gustaf E Rydell; Göteborgs universitet; []
    Nyckelord :norovirus; glycobiology; virus-like particle; FUT2; ABO H histo-blood group antigen; sialyl Lewis x; neoglycoprotein; glycosphingolipid; QCM-D; supported lipid bilayer;

    Sammanfattning : Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using virus-like particles (VLPs) have suggested susceptibility to norovirus infection to be associated with secretor status. LÄS MER