Sökning: "Ulrich Pfisterer"

Hittade 1 avhandling innehållade orden Ulrich Pfisterer.

1. 1. Direct Conversion of Human Fibroblasts to Induced Neurons

   Författare :Ulrich Pfisterer; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular Reprogramming; Direct Conversion; Human Induced Neurons; Dopaminergic; Cell Replacement Therapy; Lentiviral Vectors;

   Sammanfattning : During direct cellular reprogramming, forced expression of key transcription factors (TFs) directly converts one terminally differentiated cell type into that of another fate, exemplified in this theses by the conversion of fibroblasts into functional induced neurons (iNs). Direct conversion of mouse fibroblasts to functional neurons was established in 2010, and the starting point of my doctoral thesis was the aim to transfer iN-technology to human cells and to explore the potential of this technique in regards to generate subtype-specific neurons as well as to use these cells for transplantation studies. LÄS MER