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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Experimental radioimmunotherapy and effector mechanisms

   Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

   Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

3. 2. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

   Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

   Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

4. 3. Apoptosis induced by a human milk protein complex. Cellular and structural studies in tumour cells and bacteria

   Författare :Anders Håkansson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; nuclear uptake; caspases; mitochondria; S. pneumoniae; alpha-lactalbumin; milk; breast-feeding; Apoptosis; tumour cells; transplantation; Immunologi; serologi;

   Sammanfattning : Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. LÄS MER

5. 4. Haematopoietic Serine Proteases : A Cleavage Specificity Analysis

   Författare :Michael Thorpe; Lars Hellman; Urban Gullberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

   Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER

7. 5. Studies of Mesenchymal Progenitor Cells and Tumour Growth, Integrins and Matrix Metalloproteinases

   Författare :Lars Bryngelsson Ohlsson; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Tumour inhibition; cancer; onkologi; cancerology; Cytologi; oncology; Cytology; Biologi; Biology; Medicin människa och djur ; Medicine human and vertebrates ; Integrin matrix metalloproteinase interaction; Immunologi; serologi; transplantation; Proteins; enzymology; Proteiner; enzymologi; serology; Mesenchumal progenitor cells;

   Sammanfattning : In this thesis we characterize the effect of mesenchymal progenitor cells (MPCs) on tumour growth, and show that MPCs can have inhibitory effects on tumour development. We developed a method to subcutaneously transplant tumour cells, cultured in vitro in a pre-formed gelatin matrix, that made it possible to study the early phases of tumour development. LÄS MER