Sökning: "Tumour DNA"

Visar resultat 1 - 5 av 173 avhandlingar innehållade orden Tumour DNA.

  1. 1. Salivary gland neoplasms : studies on the cytoskeleton, the secretory apparatus and the nuclear DNA content

    Författare :Hans Gustafsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salivary gland neoplasms; intermediate filaments; immuno- histochemistry; ultrastructure; DNA; development; histogenesis; progno¬sis;

    Sammanfattning : The heterogeneity of salivary gland neoplasms have made classification and prognostication of these tumours sometimes difficult, and the in­troduction of techniques, such as enzyme and carbohydrate histochemis­try and electron microscopy have only to a certain extent increased our knowledge in these respects. In the present study immunohistochemical methods have been used to identify intermediate filament proteins (IFP) in normal fetal and adult parotid glands, as well as in salivary neo­plasms. LÄS MER

  3. 2. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

    Författare :Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

    Sammanfattning : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. LÄS MER

  4. 3. Specific anti-tumour effects of 6-diazo-5-oxo-L-norleucine (DON) on carcinoid tumour cells

    Författare :Feng Wu; Uppsala universitet; []
    Nyckelord :Medical sciences; carcinoid tumour; diazo-oxo-L-norleucine; mitochondria; apoptosis; PET; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Glutamine is essential for cell growth. 6-diazo-5-oxo-L-norleucine (DON) is a rather old anti-tumour drug developed as a glutamine antagonist. Previous clinical trials with DON, not including carcinoid tumours, did not prove convincing. Hence the drug was not further used. LÄS MER

  5. 4. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

    Författare :Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. LÄS MER

  7. 5. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

    Författare :Annabelle Forsmark; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

    Sammanfattning : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. LÄS MER