Sökning: "Tucker model"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Tucker model.

  1. 1. Involvement of Membrane Transport Proteins in Intestinal Absorption and Hepatic Disposition of Drugs Using Fexofenadine as a Model Drug

    Författare :Niclas Petri; Hans Lennernäs; Geoffrey Tucker; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Fexofenadine; OATP; P-glycoprotein; Organic Anion Transporters; ATP-Binding Cassette Transporters; membrane transport proteins; Bioavailability; Biopharmaceutics; Biofarmaci; Biopharmacy; Biofarmaci;

    Sammanfattning : The aims of this thesis were to study the in vivo relevance of membrane transporters for intestinal absorption and the hepatic disposition of drugs in humans and preclinical models. Fexofenadine is a substrate for ABCB1 (P-glycoprotein) and members of the organic anion transporting polypeptide (OATP/SLCO) family. LÄS MER

  3. 2. Radiation-Induced Damage Processes in Nuclear Reactor Environments

    Författare :Elin Toijer; Pär Olsson; Julie Tucker; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysik; Physics;

    Sammanfattning : It is essential that the materials used in nuclear reactor applications maintain their structural integrity. However, consequences of the strong radiation field in the reactor core include radiolysis of the water surrounding the materials, as well as direct defect generation in the material itself. LÄS MER

  4. 3. Optimal adaptive designs and adaptive randomization techniques for clinical trials

    Författare :Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

    Sammanfattning : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. LÄS MER

  5. 4. The role of Nkx3.2 and Gdf5 during zebrafish skeletal development

    Författare :Laura Waldmann; Tatjana Haitina; Abigail Tucker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nkx3.2; Gdf5; zebrafish; jaw joint; joints; axial skeleton; appendicular skeleton; fin; enhancer conservation; CRISPR Cas9; OPT;

    Sammanfattning : The vertebrate skeleton is composed of bony and cartilaginous structures that are developed under the control of numerous genetic networks. The transcription factor Nkx3. LÄS MER

  7. 5. Algorithms in data mining using matrix and tensor methods

    Författare :Berkant Savas; Lars Eldén; Lieven De Lathauwer; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Volume; Minimization criterion; Determinant; Rank deficient matrix; Reduced rank regression; System identification; Rank reduction; Volume minimization; General algorithm; Handwritten digit classification; Tensors; Higher order singular value decomposition; Tensor approximation; Least squares; Tucker model; Multilinear algebra; Notation; Contraction; Tensor matricization; Newton s method; Grassmann manifolds; Product manifolds; Quasi-Newton algorithms; BFGS and L-BFGS; Symmetric tensor approximation; Local intrinsic coordinates; Global embedded coordinates; ; Numerical analysis; Numerisk analys;

    Sammanfattning : In many fields of science, engineering, and economics large amounts of data are stored and there is a need to analyze these data in order to extract information for various purposes. Data mining is a general concept involving different tools for performing this kind of analysis. LÄS MER