Sökning: "Transcriptome"

Visar resultat 1 - 5 av 326 avhandlingar innehållade ordet Transcriptome.

  1. 1. On Transcriptome Sequencing

    Författare :Daniel Klevebring; Joakim Lundeberg; Ulf Gyllensten; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA-seq; DNA sequencing; gene expression profiling; non-coding RNA; small RNA; Functional genomics; Funktionsgenomik; Bioinformatics; Bioinformatik; Genetics; Genetik; Molecular biology; Molekylärbiologi; Cell biology; Cellbiologi;

    Sammanfattning : This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. LÄS MER

  3. 2. Interpreting the human transcriptome

    Författare :Beata Werne Solnestam; Joakim Lundeberg; Piero Carninci; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA sequencing; high-throughput sequencing; gene expression profiling; multiplex amplification; Bioteknologi; Biotechnology;

    Sammanfattning : The human body is made of billions of cells and nearly all have the same genome. However, there is a high diversity of cells, resulted from what part of the genome the cells use, i.e. which RNA molecules are expressed. LÄS MER

  4. 3. The art of transcriptome reconstruction : with applications in Picea abies (L.) H. Karst

    Författare :Karl Johan Westrin; Olof Emanuelsson; Henric Zazzi; Lukas Käll; Jens Sundström; Jarkko Salojärvi; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcriptome reconstruction; transcriptome assembly; transcript isoform detection; Picea abies; acrocona; cone setting; differential expression; gene families; miRNA; quality assessment; transkriptomrekonstruktion; sammansättning av transkriptom; detektering av transkriptisoform; rödgran; kottegran; kottsättning; differentiellt uttryck; genfamiljer; kvalitetsutvärdering; miRNA; Biotechnology; Bioteknologi;

    Sammanfattning : Transcriptome reconstruction is an important component in the bioinformatical part of transcriptome studies. When a reference genome is missing, highly fragmented or incomplete, a de novo transcriptome assembly is the transcriptome reconstruction approach of choice, since in such situations, a simple alignment (or mapping) would not necessarily give all theinformation concerning splice junctions, isoforms or even the full extent of the gene. LÄS MER

  5. 4. Mining the transcriptome - methods and applications

    Författare :Valtteri Wirta; Joakim Lundeberg; John Quackenbush; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcriptome; gene expression profiling; EST; microarray; RNA amplification; stem cells; neurosphere; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Regulation of gene expression occupies a central role in the control of the flow of genetic information from genes to proteins. Regulatory events on multiple levels ensure that the majority of the genes are expressed under controlled circumstances to yield temporally controlled, cell and tissue-specific expression patterns. LÄS MER

  7. 5. Diversifying the transcriptome : Adenosine-to-inosine RNA editing in the mammalian brain

    Författare :Albin Widmark; Neus Visa; Joshua Rosenthal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; microRNA; brain development; neuron; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Metazoan transcriptomes are extensively modified by adenosine-to-inosine (A-to-I) RNA editing, a process by which adenosines within double-stranded RNA are enzymatically deaminated to form inosines. Inosines has base-pairing characteristics similar to guanosine, meaning that A-to-I RNA editing results in functional rewriting of transcripts, affecting many biological processes. LÄS MER