Sökning: "Thyroid gland"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Thyroid gland.

  1. 1. Thyroid cancer : studies on etiology and prognosis

    Författare :Arne Hallquist; Lennart Hardell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thyroid cancer; prognostic factors; etiology; occupation; medical ionizing radiation; reproductive; and family factors;

    Sammanfattning : Thyroid cancer constitutes about 1% of all malignant tumours and the incidence is increasing in Sweden. It is rare in children before the age of 10. During puberty the female to male ratio increases to be two to three times more common in females. The ratio remains constant until menopause and thereafter declines. LÄS MER

  3. 2. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Författare :Madeleine Nordén; Göteborgs universitet; []
    Nyckelord :thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Sammanfattning : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. LÄS MER

  4. 3. Molecular regulation of thyroid development. New mechanisms of normal and defective morphogenesis

    Författare :Henrik Fagman; Göteborgs universitet; []
    Nyckelord :thyroid; congenital hypothyroidism; thyroid dysgenesis; cadherins; pharyngeal arch arteries; Shh; Tbx1;

    Sammanfattning : Congenital hypothyroidism (CH) is untreated a major cause of mental retardation. The majority of cases are due to malformations of the gland (dysgenesis). Little is known of molecular mechanisms regulating thyroid morphogenesis. LÄS MER

  5. 4. Microdosimetry of radiohalogens in thyroid models

    Författare :Anders Josefsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microdosimetry; radiohalogens; radioiodine; astatine-211; thyroid gland; man; rat; mouse;

    Sammanfattning : The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to the same carrier molecule, give many advantages, for example, by enabling relevant biodistribution and dosimetric studies important for dose-planning before radionuclide therapy. LÄS MER

  7. 5. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure

    Författare :Nils Rudqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; iodine-131; radionuclide therapy; nuclear medicine; environmental exposure; thyroid; radiation biology; transcriptomics; proteomics; ionizing radiation; toxicity; normal tissue damage; microarray; LC-MS; biomarker;

    Sammanfattning : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. LÄS MER