Sökning: "Thiazolidinediones"
Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet Thiazolidinediones.
1. Regulation of intracellular signaling events that modulate insulin action
Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER
2. Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
Sammanfattning : Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. LÄS MER
3. Post-transplantation Hypercholesterolaemia
Sammanfattning : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. LÄS MER
4. Molecular characterization of insulin resistance in the adipose tissue and the effects of thiazolidinediones
Sammanfattning : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many contries. Insulin resistance plays a central role in the pathogenesis of Type 2 diabetes and can be present for a decade or more before onset of the disease. LÄS MER
5. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise
Sammanfattning : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. LÄS MER