Sökning: "Tandem mass spectrometry"

Visar resultat 1 - 5 av 133 avhandlingar innehållade orden Tandem mass spectrometry.

  1. 1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry

    Författare :Maria Fälth Savitski; Per Andrén; David Fenyö; Per Svenningsson; Ronald Beavis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. LÄS MER

  3. 2. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Författare :Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. LÄS MER

  4. 3. Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications

    Författare :My Moberg; Jonas Bergquist; Karin E. Markides; Dan Bylund; Douglas B. Kell; Uppsala universitet; []
    Nyckelord :Analytical chemistry; liquid chromatography; mass spectrometry; tandem mass spectrometry; electrospray ionization; inductively coupled plasma; chemometrics; optimization; multivariate data analysis; design of experiments; response surface model; siderophore; azathioprine; peptide; Analytisk kemi;

    Sammanfattning : Liquid chromatography (LC) coupled to mass spectrometry (MS) offers highly selective and sensitive analysis of a wide variety of compounds. However, the use of hyphenated experimental set-ups implies that many parameters may have an effect on the studied response. LÄS MER

  5. 4. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

    Författare :Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. LÄS MER

  7. 5. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry

    Författare :Christopher Adams; Roman Zubarev; Göran Possnert; Carlito Lebrilla; Uppsala universitet; []
    Nyckelord :Engineering physics; Protein Structure; Mass Spectrometry; Electron Capture Dissociation; Tandem Mass Spectrometry; Teknisk fysik;

    Sammanfattning : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). LÄS MER