Sökning: "TUNEL Assay"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden TUNEL Assay.

1. 1. Programmed Cell Death in Xylem Development

   Författare :Laetitia Charleen Courtois-Moreau; Hannele Tuominen; Stefan Jansson; Christina Dixelius; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PCD Programmed Cell Death ; Xylem; Apoptosis; Autophagy; Secondary Cell Walls; Microscopy; Microarrays; Comet Assay; TUNEL Assay; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Concerns about climate changes and scarcity of fossil fuels are rising. Hence wood is becoming an attractive source of renewable energy and raw material and these new dimensions have prompted increasing interest in wood formation in trees, in both the scientific community and wider public. LÄS MER

3. 2. Functional studies of calcein acetoxymethyl ester in human tumor cells

   Författare :Gunnar Liminga; Uppsala universitet; []
   Nyckelord :Medical sciences; Calcein AM; Calcein; Functional assay; Drug resistance; Cytotoxicity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : A fluorometric assay for functional measurement of P-glycoprotein 170 (Pgp) mediated transport in cell lines, using the acetoxymethyl ester of calcein (calcein/AM) as a probe was established. The myeloma cell line RPMI 8226/S and the two Pgp-expressing doxorubicin resistant subcell lines 8226/dox6 (low) and 8226/dox40 (high) were used. LÄS MER

4. 3. Molecular aspects of cellular radiosensitivity in small cell lung carcinoma

   Författare :Florin Sirzén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :lung carcinoma; radiosensitivity; DNA double-strand breaks; DNA-dependent protein kinase; cell cycle checkpoints; apoptosis;

   Sammanfattning : To clarify some important molecular aspects of radiosensitivity (RS) in small cell (SCLC) compared with non small cell (NSCLC) lung carcinoma, five studies focusing on DNA damage repair, cell cycle checkpoints and apoptosis were performed. As repair of DNA double-strand breaks (DNA dsb), a critical DNA lesion, may be an important determinant of cellular RS, induction and rejoining of DNA dsb were studied using pulsed field gel electrophoresis in a radiosensitive SCLC line, U-1285 and a radioresistant NSCLC line, U-1810 (paper I). LÄS MER

5. 4. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

   Författare :Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

   Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER

7. 5. In vitro wound healing characteristics of amelogenins

   Författare :Sofia Almqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amelogenins; extracellular matrix; cell culture; macrophage; fibroblast; endothelial cell; integrin; cytokine; inflammation; wound healing tissue repair;

   Sammanfattning : Wound healing involves the co-ordinated actions of several cell types, soluble cell mediators and extracellular matrix (ECM). This research project intended to investigate the role of certain ECM proteins in different processes during tissue repair by studying the interaction between dermal cells and ECM. LÄS MER