Sökning: "TIMP-2"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet TIMP-2.

  1. 1. Structure and function of MMP-2 and its inhibitor TIMP-2

    Författare :Ari Tuuttila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Metalloproteinases; MMP-2; TIMP-2; extracellular matrix; crystallography; protein structure;

    Sammanfattning : Animal cells secrete various enzymes capable of degrading the extracellular matrix. One of the most studied groups of these are the matrix metalloproteinases (MMPs). This group of zinc containing endopeptidases consists at present of 26 members and this number is still increasing. LÄS MER

  3. 2. Human ovulation. Studies on collagens, gelatinases and tissue inhibitors of metalloproteinases

    Författare :Anna Karin Lind; Göteborgs universitet; []
    Nyckelord :ovulation; ovary; human; follicle; collagen; MMP and TIMP;

    Sammanfattning : Ovulation is a highly regulated process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of a fertilizable oocyte. This unique biological process is initiated by the LH-surge, which induces major vascular changes and remodelling of the extracellular matrix (ECM) in and around the follicle. LÄS MER

  4. 3. Biomarkers and surgical predictors in temporomandibular joint disease

    Författare :Mattias Ulmner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Temporomandibular joint (TMJ) disc displacement (DD) is associated with pain and impaired function and has two main sub-diagnoses, DD with or without reduction (DDwR/DDwoR). DD synovial tissue has been sparsely investigated, and further characterisation is needed. LÄS MER

  5. 4. Inflammatory response in periodontal tissue in children with Down syndrome

    Författare :Georgios Tsilingaridis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Periodontal diseases are inflammatory diseases affecting the supporting tissues of the teeth. Subjects with Down syndrome have a higher prevalence of periodontal disease compared to healthy controls. Periodontal disease in Down syndrome is considered to be multifactorial, although the aetiology is uncertain. LÄS MER

  7. 5. Towards surgical use of matrix metalloproteinase biology

    Författare :Björn Pasternak; Per Aspenberg; Pentti Tengvall; Yrjö T Konttinen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; Orthopaedics; Ortopedi;

    Sammanfattning : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. LÄS MER