Sökning: "TGF-b1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet TGF-b1.

  1. 1. On cellular immunology in chronic idiopathic thrombocytopenic purpura (ITP)

    Författare :Per-Ola Andersson; Göteborgs universitet; []
    Nyckelord :chronic ITP; T-cells; TGF-b1; Th3; cell-mediated cytotoxicity; KIR; DNA microarray;

    Sammanfattning : Chronic idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease characterized by a low platelet count and mucocutaneous bleedings. Chronic ITP is considered to be mediated by autoantibodies leading to premature destruction of platelets in the reticuloendothelial system. LÄS MER

  3. 2. Interactions between the stroma and thyroid epithelial cells of normal and malignant origin

    Författare :Thérèse Dahlman; Uppsala universitet; []
    Nyckelord :Medical sciences; Thyroid gland; carcinoma; collagen type I; EGF; TGF-b1; interaction; integrins; E-cadherin; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Endocrine and locally produced factors as well as interactions between epithelial cells and the stroma important in the control of growth and function of the thyroid gland. In this study, the effects of, and mechanism(s) for, such cross-talk under some normal and pathological conditions were investigated. LÄS MER

  4. 3. Transforming Growth Factor-b, Regulatory functions on normal lymphocytes and tumor outgrowth Regulatory functions on normal lymphocytes and tumor outgrowth

    Författare :Åsa Schiött; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-b; monocyte; rat; costimulation; Th2; ERK; tumor; TIL; Immunology; serology; Immunologi; transplantation; T-lymphocyte; serologi;

    Sammanfattning : Transforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. LÄS MER

  5. 4. Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides

    Författare :Mark Lal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; diabetes; Na; K-ATPase; ouabain; oxidative stress;

    Sammanfattning : The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current study we have investigated the intracellular signalling cascades activated downstream of two separate stimuli: the diabetic milieu and the cardiac glycoside, ouabain. LÄS MER

  7. 5. Studies of human endogenous retroviruses and of the TGF-beta signaling pathway

    Författare :Christian Kjellman; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high-density filter array; gliom; TGF-beta; XA34; Human endogenous retrovirus; HERV-F; transplantation; serologi; Immunologi; serology; Immunology;

    Sammanfattning : The human genome, in common with all mammalian genomes, carries a high load of inheritable retroviral sequences. We have identified and characterized a novel family of these endogenous retroviruses and have named this family HERV-F as based on the primer binding sites of three members. LÄS MER