Sökning: "Systemic RNAi"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Systemic RNAi.

  1. 1. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans

    Författare :Benjamin T. Holmgren; Andrea Hinas; Gerhart Wagner; Peter Brodersen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; Endomembrane system; Late endosome; SID-5; SEC-22; SYX-6; C12D8.1; RNA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. LÄS MER

  3. 2. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans

    Författare :Yani Zhao; Andrea Hinas; Staffan Svärd; Simon Tuck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; late endosomes MVBs; SID-5; SEC-22; SYX-6; C12D8.1; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. LÄS MER

  4. 3. Genome dynamics and virulence in the human pathogen Candida glabrata

    Författare :Khadija Mohamed Ahmad; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pathogenic yeast; Candida glabrata; small chromosomes; Genome rearrangement; Haploid and diploid yeast; RNA interference.;

    Sammanfattning : Although the yeast Candida glabrata is considered to be a part of the commensal microflora in healthy individuals, during the last years it has been frequently isolated from patients with mucosal and systemic fungal infections. Now it is considered as the second most frequently isolated pathogenic yeast after Candida albicans. Despite its name, C. LÄS MER

  5. 4. CELL PENETRATING PEPTIDES : CHEMICAL MODIFICATION AND FORMULATION DEVELOPMENT

    Författare :Kariem Ezzat; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Cell penetrating peptides (CPPs) have been extensively studied and exploited as drug delivery vectors for a wide variety of therapeu-tic cargos. However, several issues remain to be addressed regarding the enhancement of their efficiency and stability. LÄS MER

  7. 5. Signaling and transcriptional regulation of antimicrobial peptide genes in Drosophila melanogaster

    Författare :Hanna Uvell; Ylva Engström; Won-Jae Lee; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptides; drosophila; immunity; transcriptiona regulation; Molecular biology; Molekylärbiologi;

    Sammanfattning : Insects rely solely on innate immune reactions for protection against infect-ing microbes in their environment. In Drosophila, one major defense mechanism is the production of a battery of antimicrobial peptides (AMPs). LÄS MER