Sökning: "Susanne Tornhamre"

Hittade 2 avhandlingar innehållade orden Susanne Tornhamre.

1. 1. Studies on the formation of leukotriene C4 and lipoxins from leukotriene A4 in human platelets

   Författare :Susanne Tornhamre; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transform the unstable epoxide leukotriene (LT)A4 to the potent inflammatory agent LTC4 and lipoxins, a group of trihydroxylated tetraene-containing eicosanoids, which recently have been suggested to have an anti-inflammatory role. A novel pathway for the formation of lipoxin (LX)A4 via platelet lipoxygenation of SS,6R-diHETE and 5S,6S-diHETE, enzymatic/non-enzymatic hydrolysis products of LTA4, was discovered in human platelets. LÄS MER

3. 2. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia

   Författare :Cecilia Roos; Susanne Tornhamre; Anita Sjölander; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leukotriene C4 synthase; chronic myeloid leukaemia; p210 BCR-ABL; myelopoiesis; imatinib mesylate; Cell biology; Cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

   Sammanfattning : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). LÄS MER