Sökning: "Splice variants"

Visar resultat 1 - 5 av 71 avhandlingar innehållade orden Splice variants.

  1. 1. Gene Expression in Cancer Cells : Detection of Splice Variants, Allele-specific Expression and DNA Methylation

    Författare :Lili Milani; Ann-Christine Syvänen; Thomas R. Gingeras; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The human genome sequencing project has provided a wealth of information on sequence variation between individuals. The surprisingly low number of genes in the human genome is compensated for by a complex regulation of gene expression. LÄS MER

  3. 2. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

    Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER

  4. 3. C-SRC expression in neuroendocrine tumors : neuronal splice variants of C-SRC as diagnostic and prognostic markers in neuroblastoma

    Författare :Catarina Bjelfman; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Characterisation of integrin splice variants and the interaction between integrins and the urokinase receptor

    Författare :Gunbjørg Svineng; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; integrin β1; alternative splicing; Alu element; urokinase receptor; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Integrins are a family of receptors involved in adhesion to extracellular matrix proteins and in cell-cell contacts. Each integrin consists of one a and one β subunit. Our main interest has been the β1 subunit and its splice variants. LÄS MER

  7. 5. Hedgehog signaling in rhabdomyosarcoma : role of GLI factors and splice variants in signal transduction

    Författare :Ulrica Tostar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rhabdomyosarcoma (RMS) is the most common soft-tissue childhood cancer. Deregulation of the Hedgehog (HH) signaling pathway, which is essential for proper embryonic development, has been implicated as a driving force for this cancer. LÄS MER