Sökning: "Sialyl Lewis x"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Sialyl Lewis x.

  1. 1. Synthetic analogs of sialyl Lewis x

    Författare :Ulf Ellervik; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Sammanfattning : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. LÄS MER

  3. 2. Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation

    Författare :Jafar Mahdavi; Henrik Clausen; Umeå universitet; []
    Nyckelord :H. pylori; BabA; adhesin; Lewis b; MUC5AC; sialyl-dimeric-Lewis x; chronic inflammation; SabA; Lewis x; LPS; odontologi; Odontology;

    Sammanfattning : Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which is also highly associated with gastric cancer. The pathogenesis of severe gastric disorders caused by H. LÄS MER

  4. 3. Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion

    Författare :Gustaf E Rydell; Göteborgs universitet; []
    Nyckelord :norovirus; glycobiology; virus-like particle; FUT2; ABO H histo-blood group antigen; sialyl Lewis x; neoglycoprotein; glycosphingolipid; QCM-D; supported lipid bilayer;

    Sammanfattning : Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using virus-like particles (VLPs) have suggested susceptibility to norovirus infection to be associated with secretor status. LÄS MER

  5. 4. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

    Författare :Kristina Nyström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

    Sammanfattning : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. LÄS MER

  7. 5. Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell

    Författare :Rickard Nordén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Glycobiology; Herpesvirus; Selectin ligand;

    Sammanfattning : Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. LÄS MER