Sökning: "Serotonin reuptake inhibition"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden Serotonin reuptake inhibition.

  1. 6. Central nervous system targets for micturition control

    Författare :Rikard Pehrson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; central nervous system; Micturition; 5-HT; GABA; tramadol; NAD-299; CGP62349; apomorphine; cerebral infarction; toxikologi; farmaci; farmakognosi; Farmakologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences;

    Sammanfattning : Normal urine storage and bladder emptying are controlled by the central (CNS) as well as the peripheral nervous system. Dysfunction of these mechanisms can lead to urinary incontinence. Urinary tract dysfunctions have symptomatically been treated mainly with drugs acting peripherally. LÄS MER

  3. 7. Utility of combined treatment with antipsychotic and antidepressant drugs : scientific rationales and clinical implications

    Författare :Carl Björkholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The atypical antipsychotic drug (APD) clozapine is the most efficacious APD in treatment-resistant schizophrenia including negative symptoms and cognitive impairment, and still lacks extrapyramidal side effects (EPS). Clozapine, which also possesses an antidepressant effect and can be used as monotherapy in bipolar disorder, has a broad receptor binding profile with higher affinity for the α2-adrenoceptor and several serotonergic receptors than D2 receptor, enhances dopamine output in the medial prefrontal cortex (mPFC) and facilitates glutamatergic NMDA receptor-mediated transmission in pyramidal cells in the same brain region. LÄS MER

  4. 8. Brain mechanisms in pain regulation

    Författare :Karin B Jensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The subjective sensitivity to pain differs greatly between individuals and neuroimaging has contributed to the understanding of the cerebral mechanisms involved in pain regulation. The descending pain inhibitory circuitry is a well defined cerebral network that enables regulation of afferent nociceptive information. LÄS MER

  5. 9. Effect of pharmacological treatment of serotonergic function in depression

    Författare :Aram El Khoury; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sertonin depression; platelets; HPA-axis; intracellular calcium; lithium; SSRI NRI;

    Sammanfattning : Since its identification in raphe neurons of the central nervous system (CNS), the biogenic amine serotonin (5- hydroxytryptamin, 5-HT) has been implicated in the etiology and pathophysiology of affective disorders, such as depression. It has been proposed that enhancement of central serotonergic transmission may underlie the therapeutic response to different types of antidepressant drugs. LÄS MER

  7. 10. Stress system function in abdominal obesity. The hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in middle-aged men

    Författare :Thomas Ljung; Göteborgs universitet; []
    Nyckelord :Abdominal obesity; stress; HPA axis; cortisol; glucocorticoid receptors; sympathetic nervous system; catecholamines; depression; SSRI;

    Sammanfattning : Background: There is a strong relationship between central (abdominal, visceral) obesity, impaired glucose tolerance, insulin resistance, dyslipidemia and elevated blood pressure. These abnormalities are included in the term Metabolic Syndrome, and indicate an elevated risk for cardiovascular disease and diabetes type 2. LÄS MER