Sökning: "SLCO1B1"

Hittade 4 avhandlingar innehållade ordet SLCO1B1.

1. 1. In vitro and in silico prediction of drug-drug interactions with transport proteins

   Författare :Gustav Ahlin; Per Artursson; Christel Bergström; Johan Karlsson; Jörg König; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; Pharmaceutics; Galenisk farmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

   Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER

3. 2. Incidence, predictors and biomarkers for antiretroviral and/or anti-tuberculosis drugs induced liver injury

   Författare :Getnet Yimer Ali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Anti-tuberculosis and/or antiretroviral drugs induced liver injury (DILI) is a major challenge when managing TB and/or HIV patients. The aims of this thesis were to identify incidence, risk factors, and management of DILI among 4 different treatment groups namely; HIV positive individuals with no TB co-infection and had a CD4 count of < 200 cells/μl (taking ARV drugs alone = arm 1), TB-HIV co-infected patients with a CD4 count of < 200 cells/μl (taking both anti-TB and ARV drugs = arm 2), TB-HIV co-infected patients with a CD4 count of > 200 cells/μl (taking anti-TB alone = arm 3), HIV negative TB patients (taking anti-TB alone = arm 4). LÄS MER

4. 3. Pharmacokinetic and pharmacogenetic aspects of drug-drug interactions between antiretroviral and anti-tuberculosis drugs in Ethiopian patients : implication for optimization of TB-HIV co-treatment

   Författare :Abiy Habtewolde Eyakem; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : TB and HIV are immuno-pathologically interacting epidemic infectious diseases affecting the lives of millions globally & sub-Saharan African region accounts the highest burden of both diseases. Although effective therapies are available for the management of each, TB-HIV co-treatment has faced challenges mainly due to drug-drug interactions & overlapping drug toxicities. LÄS MER

5. 4. Optimization of HIV and tuberculosis co-treatment in Tanzania : drug-drug interactions and clinical outcomes

   Författare :Sabina Mugusi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV;

   Sammanfattning : Background: Sub-Saharan Africa has been greatly affected by the HIV epidemic, with an estimated 23.5 million people living with HIV/AIDS (PLWHA) residing within this region by the end of 2011, being the leading course of morbidity and mortality. Tanzania is one of the countries in this region with an HIV prevalence of 5.7% i. LÄS MER