Sökning: "SH-SY5Y"
Visar resultat 1 - 5 av 55 avhandlingar innehållade ordet SH-SY5Y.
1. Ras-MAPK signaling in differentiating SH-SY5Y human neuroblastoma cells
Sammanfattning : Neuroblastoma is a malignant childhood cancer, originating from sympathetic neuroblasts of the peripheral nervous system. Neuroblastoma is a heterogenous group of tumours, while some are highly malignant others can spontaneosly mature into a more benign form or regress. LÄS MER
2. Neuroblastoma SH-SY5Y and neural progenitor C17.2 cell lines as models for neurotoxicological studies
Sammanfattning : We are surrounded by chemicals, thus understanding how exposure to these chemicals affect us during our life is of great social importance. In order to predict human acute toxicity of chemicals, cosmetics or drugs, development of novel in vitro test strategies is required. LÄS MER
3. Uncoupling Proteins : Regulation by IGF-1 and Neuroprotection during Hyperglycemia in Vitro
Sammanfattning : Diabetic neuropathy is believed to arise due to oxidative stress following hyperglycemic situations. Uncoupling proteins (UCPs) constitute a subgroup of mitochondrial transporter proteins with putative antioxidant properties. LÄS MER
4. Effects of ethanol on muscarinic acetylcholine receptors in nerve cells
Sammanfattning : This thesis focused on the mechanisms involved in the effects of long-term ethanol treatment on mAChRs and their coupled-signal transduction pathway in human neuroblastoma SH-SY5Y cells. All 5 subtypes of mAChRs were expressed in these cells. LÄS MER
5. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1
Sammanfattning : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. LÄS MER
