Sökning: "SCID mice"

Visar resultat 1 - 5 av 49 avhandlingar innehållade orden SCID mice.

1. 1. T-cell Differentiation and Immunological Homeostasis in Lymphopenic and Kappa Light Chain Deficient Mice

   Författare :Frida Ekholm Pettersson; Fredrik Ivars; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; T cells; differentiation; homeostasis; cytokines; mice; SCID; κ-deficient; Biokemi; Biochemistry; Biokemi; immunologi; Immunology;

   Sammanfattning : T lymphocytes are primarily involved in adaptive, cell-mediated, immune reactions. In this thesis T cells were studied regarding central and peripheral differentiation and homeostatic mechanisms for maintanance of the immune repertoire.The influence by mature T cells on thymic development was studied in C. LÄS MER

3. 2. Development and validation of a localized murine candidiasis model : The pathogenesis, chemotheraphy and defense mechanisms to Candida mastitis in the lactating mouse

   Författare :Faisal Abdi Guhad; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Murine model; Candida albicans; Pathogenesis; Virulence factors; Amphotericin B; Fluconazole; Complement activation; C3c; SCID mice; Nude mice; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : A murine model of localized candidiasis (mastitis) was developed. The model was analyzed withrespect to its discriminative abilities through investigation of the virulence properties of C.albicans mutant strains compared with the wild-type parental strain. LÄS MER

4. 3. Immunomodulatory properties of steroid hormones

   Författare :Maria Taube; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DTH; oestradiol; corticosteroids; T cells; SCID mice; adoptive transfer; thymus; spleen.;

   Sammanfattning : Recent epidemiological, clinical and experimental evidence have suggested that steroid hormones play an important role in immune responses and in immune-mediated diseases. Many autoimmune diseases are treated with corticosteroids. LÄS MER

5. 4. Humanized mice as a model to study human immunity

   Författare :Frank Heuts; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mice with human immune systems have evolved over the last three decades. Over the years, these humanized mouse models have provided us with valuable information on human immunity. Recent developments in recipient mouse strains and engraftment protocols have resulted in models with high level of de novo formation of human immune cells. LÄS MER

7. 5. The chimeric SCID mouse in studies of the human immune system

   Författare :Mohammad Reza Abedi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Several methods have been developed to transfer components of the human immune system into mice. In particular, the adoptive transfer of human Iymphoid cells or tissues into mice with severe combined immunodeficiency (SCID mice) has demonstrated the general applicability of such an approach. LÄS MER