Sökning: "SCI"

Visar resultat 1 - 5 av 346 avhandlingar innehållade ordet SCI.

  1. 1. Exploring the transcriptional space

    Författare :Joseph Bergenstråhle; Joakim Lundeberg; Jay W. Shin; KTH; []
    Nyckelord :Transcriptomics Spatial; Bioteknologi; Biotechnology;

    Sammanfattning : Transcriptomics promises biological insight into gene regulation, cell diversity, and mechanistic understanding of dysfunction. Driven by technological advancements in sequencing technologies, the field has witnessed an exponential growth in data output. Not only has the amount of raw data increased tremendously but it’s granularity as well. LÄS MER

  3. 2. Method development for affinity capillary electrophoresis of ß2-glycoprotein I and biological ligands

    Författare :Maria E. Bohlin; Lars G Blomberg; Niels H H Heegaard; Jan Leo Reubsaet; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Capillary Electrophoresis; β2-glycoprotein I; acidic pretreatment; pH hysteresis effect; Affinity Capillary Electrophoresis; Kemi; Chemistry;

    Sammanfattning : The final goal of this study is to establish a microscale analysis method that allows solution phase characterization of interactions between β2-glycoprotein I (β2gpI) and some of its ligands. Human β2gpI is a phospholipid- and heparin-binding plasma glycoprotein. LÄS MER

  4. 3. Invasive treatment of coronary artery disease : Aspects on antithrombotic and percutaneous treatment options

    Författare :Per Grimfjärd; Stefan James; Christoph Varenhorst; P Hedberg; Lene Holmvang; Uppsala universitet; []
    Nyckelord :PCI; STEMI; stent thrombosis; bivalirudin; heparin; bioresorbable scaffold; cangrelor; drug eluting stent; DES; Cardiology; Kardiologi;

    Sammanfattning : The outcome after percutaneous coronary intervention (PCI) has improved considerably thanks to more effective antithrombotic treatment strategies and improved coronary stents. Stent thrombosis (ST) is a rare complication to PCI associated with considerable mortality and morbidity. LÄS MER

  5. 4. Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies

    Författare :Álvaro Martínez Barrio; Erik Bongcam-Rudloff; Teresa K Attwood; Uppsala universitet; []
    Nyckelord :data integration; web services; protein allergology; risk assessment; cross reactivity; endogenous retroviruses; ERV; dog; canine; GWAS; genome-wide association studies;

    Sammanfattning : Recently, the pace of growth in the amount of data sources within Life Sciences has increased exponentially until pose a difficult problem to efficiently manage their integration. The data avalanche we are experiencing may be significant for a turning point in science, with a change of orientation from proprietary to publicly available data and a concomitant acceptance of studies based on the latter. LÄS MER

  7. 5. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43

    Författare :Christopher Sackmann; Martin Hallbeck; Emelie Severinsson; Poul Henning Jensen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α-synuclein; amyloid-β; TDP-43; cell to cell transmission;

    Sammanfattning : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. LÄS MER