Sökning: "Rho-kinase inhibition"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Rho-kinase inhibition.

1. 1. Effects of Rho kinase, prostacyclin and L-arginine on microvascular permeability and perfusion

   Författare :Cornelia Lundblad; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; skeletal muscle; Rho kinase; prostacyclin; permeability; NO; experimental brain trauma; brain edema; brain contusion; microcirculation; cerebral perfusion;

   Sammanfattning : This thesis presents some effects of Rho kinase, prostacyclin (PGI2) and nitric oxide (NO) in relation to trauma and inflammation by evaluating their effects on microvascular perfusion and permeability in mouse brain and in cat skeletal muscle. PGI2 and NO are endogenous vasoactive substances produced by the endothelium. LÄS MER

3. 2. Rho-kinase signalling in systemic inflammatory responses

   Författare :Jan Slotta; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Endotoxemic liver injury is characterized by an initial release of pro-inflammatory cytokines and CXC chemokines, which leads to a recruitment of leukocytes to the liver microvasculature. The mechanisms of leukocyte recruitment are well characterized and comprise on the one hand a mechanical trapping of leukocytes in sinusoids, and on the other hand a multi-step process of leukocyte-endothelial cell interactions in postsinusoidal venules. LÄS MER

4. 3. SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION

   Författare :Zirak Hasan; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; neutrophil; lung; chemokines; infection; T-cells; CD44; Rho-kinase; isoprenylation;

   Sammanfattning : Sepsis and subsequent organ failure remain the major cause of mortality in intensive care units in spite of significant research efforts. The lung is the most vulnerable organ affected by early hyper-inflammatory immune response in septic patients. LÄS MER

5. 4. Responses of fibroblasts and chondrosarcoma cells to mechanical and chemical stimuli

   Författare :Juha Piltti; Mikko Lammi; Jukka Häyrinen; Frank Beier; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-kinase inhibition; Y-27632; hypoxia; cyclic stretching; human chondrosarcoma 2 8 cells; chondrocyte phenotype; fibroblasts; proteomics; protein pathway analytics; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning : Osteoarthritis is an inflammation-related disease that progressively destroys joint cartilage. This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints. Therefore, it often restricts daily activities and the ability to work. LÄS MER

7. 5. On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

   Författare :Andrada Röme; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiation; colon; intestinal leakage; Leukocyte and platelet recruitment;

   Sammanfattning : Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. LÄS MER