Sökning: "RNA-sequencing"

Visar resultat 6 - 10 av 272 avhandlingar innehållade ordet RNA-sequencing.

  1. 6. Development and application of spatial transcriptomics methods

    Författare :Zaneta Andrusivova; Joakim Lundeberg; Jay W. Shin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; Spatial Transcriptomics; RNA sequencing; Biotechnology; Bioteknologi;

    Sammanfattning : Transcriptomics is one of the pivotal fields in molecular biology, enabling comprehensive analysis of gene expression patterns. Recent advancements in the biotechnology field have transformed the transcriptomics research, providing insights into the complexity of cellular processes in a greater detail. LÄS MER

  3. 7. Analysis of RNA and DNA sequencing data : Improved bioinformatics applications

    Författare :Benjamín Sigurgeirsson; Joakim Lundeberg; Simon Anders; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA sequencing; exome sequencing; bioinformatics; gene expression; differential expression; variant calling; Bioteknologi; Biotechnology;

    Sammanfattning : Massively parallel sequencing has rapidly revolutionized DNA and RNA research. Sample preparations are steadfastly advancing, sequencing costs have plummeted and throughput is ever growing. This progress has resulted in exponential growth in data generation with a corresponding demand for bioinformatic solutions. LÄS MER

  4. 8. Post-transcriptional regulation by RNases in Streptococcus pyogenes

    Författare :Anne-Laure Lécrivain; Emmanuelle Charpentier; Bernt Eric Uhlin; Tracy Nissan; Ciarán Condon; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Post-transcriptional regulation; mRNA decay; RNA sequencing; RNase Y; RNase III; YhaM; PNPase; RNase R; RNase J1; Streptococcus pyogenes.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribonucleases (RNases) are proteins that adjust cellular RNA levels by processing RNA transcripts, leading to their stabilization or degradation. RNases are grouped based on their ability to cleave the transcript internally (endoRNases) or degrade the transcript starting from the ends (exoRNases). LÄS MER

  5. 9. Transcriptome-wide analysis in cells and tissues

    Författare :Sanja Vickovic; Afshin Ahmadian; Itai Yanai; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA-sequencing; single cells; spatially resolved transcriptomics; 3D profiling.; Biotechnology; Bioteknologi;

    Sammanfattning : High-throughput sequencing has greatly influenced the amount of data produced and biological questions asked and answered. Sequencing approaches have also enabled rapid development of related technological fields such as single-cell and spatially resolved expression profiling. LÄS MER

  7. 10. Mesenchymal heterogeneity in the adult human lung

    Författare :Måns Kadefors; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lung; Extracellular matrix; Adventitia; Fibroblast; mesenchymal cell; Alveolar epithelial cell; Fibrosis; Idiopathic pulmonary fibrosis; Mass spectrometry; RNA-sequencing;

    Sammanfattning : The human lung is a complex tissue consisting of a heterogeneous mix of different structures and cells, each which a specific role that together contribute to the primary function of the organ: the gas exchange. Different mesenchymal cells populate the interstitial areas around airways and blood vessels and form the connective tissue together with the extracellular matrix. LÄS MER