Sökning: "Proteoglycan metabolism"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden Proteoglycan metabolism.

  1. 16. Stress urinary incontinence in women : pathophysiological aspects

    Författare :Christian Falconer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :menopause; paraurethral connective tissue; extracellular matrix; collagen. proteoglycans; sensory innervation; intravaginal slingplasty.;

    Sammanfattning : Objective: The pathophysiology of female stress urinary incontinence (SUI) is multifactorial. In this thesis biochemical and ultrastructural changes in the paraurethral supporting connective tissue and changes in the innervation of the vaginal wall in relation to SUI have been focused upon. LÄS MER

  3. 17. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    Författare :Hooi Min Tan Grahn; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Sammanfattning : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. LÄS MER

  4. 18. Towards new therapeutic targets : identification of novel tumor markers in chronic lymphocytic leukemia

    Författare :Eva Mikaelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western world and is caused by an abnormal accumulation of B lymphocytes in peripheral blood, bone marrow and lymphoid organs. It is a disease mainly of adults. The clinical outcome of CLL may differ significantly. LÄS MER

  5. 19. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER

  7. 20. GLP-1 secretion and signaling in patients with aneurysmal enlargement of the thoracic aorta : a potential contributor to reduced prevalence of aneurysm in diabetes

    Författare :Stelia Ntika; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An aortic aneurysm is a localized dilation of the artery, greater than 50% of the normal size. It is the result of a weakening of the aortic wall, and untreated or unrecognized aortic aneurysms may be fatal due to massive internal bleeding, as a result of dissection or rupture of the aneurysm. LÄS MER