Sökning: "Protein S deficiency"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden Protein S deficiency.

1. 1. Vitamin K-dependent protein S - studies of synthesis, structure and function

   Författare :Sofia Somajo; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; coagulation; microparticles; protein C; protein S; structure; tissue factor pathway inhibitor;

   Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER

3. 2. Structural pathology and functional analysis of vitamin K-dependent protein S

   Författare :Tusar K Giri; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; Protein S; blood coagulation; thrombosis; natural mutations; in vitro characterization.; Immunology; transplantation; serologi; Immunologi; serology;

   Sammanfattning : Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. LÄS MER

4. 3. Learning from primary immunodeficiencies to treat cancer

   Författare :Mariana M S Oliveira; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent and can be characterized as primary, if the cause of disease is genetic; or secondary, if the cause of disease are extrinsic factors. LÄS MER

5. 4. Familial thrombophilia : Resistance to activated protein C and protein S deficiency

   Författare :Bengt Zöller; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Inherited resistance to activated protein C (APC-resistance) and protein S deficiency are associated with functional impairment of the protein C anticoagulant system, resulting in lifelong hypercoagulability andincreased risk of thrombosis. APC-resistance is the most common genetic cause of thrombosis being present in 20% to 60% of thrombosis patients. LÄS MER

7. 5. Analysis of Complement Deficiency States. With Focus on Molecular Characterization of C4 and Properdin Deficiency

   Författare :Gunilla Nordin Fredrikson; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; virology; bacteriology; Complement C4; Complement; Complement Screening; Deficiency; Meningococcal Disease; Properdin; Properdin Expression; Microbiology; Sequencing; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Complement deficiency is associated with an increased risk for invasive infection and immune complex disease. Screening for identification of complement-deficient patients is essential and a new ELISA-based procedure for detection of complement deficiency is described. LÄS MER