Sökning: "Postmortem human brain"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Postmortem human brain.
1. Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression
Sammanfattning : Neuropeptides represent the most diverse family of messenger molecules in the nervous system, which are co-expressed with key neurotransmitters in several brain regions. They modulate synaptic neurotransmission and have, in some cases, also trophic functions. One such neuropeptide, and the focus of the thesis, is ‘galanin’. LÄS MER
2. Genetic studies of two inherited human phenotypes : Hearing loss and monoamine oxidase activity
Sammanfattning : This thesis focuses on the identification of genetic factors underlying two inherited human phenotypes: hearing loss and monoamine oxidase activity. Non-syndromic hearing loss segregating in a Swedish family was tested for linkage to 13 previously reported candidate loci for hearing disabilities. LÄS MER
3. G-proteins and adenylyl cyclase in Alzheimer's disease postmortem brain
Sammanfattning : Alzheimer's disease (AD) is the most common type of dementia in the elderly. The major pathological changes seen in the disease are the formation of neurofibrillary tangles, of which the main component is the hyperphosphorylated form of tau, and the over accumulation of plaques formed by beta-amyloid. LÄS MER
4. In vivo quantification of extrastriatal dopamine D2 receptors in the human brain
Sammanfattning : The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. The brain imaging technology Positron Emission Tomography (PET) has since long allowed for reliable quantification of the high density of dopamine D2 receptors in large brain structures such as the neostriatum. LÄS MER
5. In vitro and postmortem studies of the brain opioid system : association to opiate dependence
Sammanfattning : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. LÄS MER