Sökning: "Population genomics"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden Population genomics.

  1. 1. Speciation genomics : A perspective from vertebrate systems

    Författare :Nagarjun Vijay; Jochen. B.W Wolf; C. Alex Buerkle; Uppsala universitet; []
    Nyckelord :evolution; speciation; genomics; vertebrate; adaptation; selection; linked selection; crow; killer whale; hybrid zone; transcriptomics; population genetics; behaviour; colouration; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Species are vital entities in biology. Species are generally considered to be discrete entities, consisting of a group of (usually interbreeding) individuals that are similar in phenotype and genetic composition, yet differ in significant ways from other species. LÄS MER

  3. 2. Genomics of population decline

    Författare :Tom van der Valk; Katerina Guschanski; Aylwyn Scally; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genetic diversity; minimal-invasive samples; population decline; inbreeding; genetic purging; eastern gorillas; Dryas monkey; Biologi med inriktning mot zooekologi; Biology with specialization in Animal Ecology;

    Sammanfattning : With human populations forecasted to grow in the next decades, many mammals face increasing anthropogenic threats. The consequential population declines are a precursor to extinctions, as small populations are not only more sensitive to stochastic events, but reduction in population size is generally also followed by a decrease in genetic diversity, which in turn reduces adaptive potential and fitness of the population. LÄS MER

  4. 3. Evolutionary genomics in Corvids : – From single nucleotides to structural variants

    Författare :Matthias H. Weissensteiner; Jochen B.W. Wolf; Manfred Grabherr; Kateryna M. Makova; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; evolutionary genetics; genomics; population genetics; selection; recombination; chromosomal features; colouration; insertion; deletion; inversion; crow; tandem repeat; transposable element; gene expression;

    Sammanfattning : Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations. LÄS MER

  5. 4. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry

    Författare :Argyri Mathioudaki; Kerstin Lindblad-Toh; Panagiotis Deloukas; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ankylosing spondylitis; breast cancer; targeted sequencing; Sweden; genetics; population stratification.; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. LÄS MER

  7. 5. Finding fitness : empirical and theoretical explorations of inferring fitness effects from population-level SNP data

    Författare :Bea Angelica Andersson; Xiao-Ru Wang; Åke Brännström; Tanja Slotte; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; distribution of fitness effects; site frequency spectra; missing data filtering; downsampling; imputation; sample size; population structure; inbreeding; selfing; homozygosity; Arabidopsis; Pinus; DFE-alpha; SLiM; population genomics; adaptation; biology; biologi; evolutionär genetik; evolutionary genetics; populationsbiologi; Population Biology; molekylärbiologi; Molecular Biology; Genetics; genetik;

    Sammanfattning : The distribution of fitness effects (DFE) describes the likelihood that a new mutation has a specific effect on the fitness of an individual in a given population. The shape of the DFE is a result of several factors such as population size, mating system and selective environment, and can in turn influence the evolutionary potential of a species. LÄS MER