Sökning: "Pitx3"

Hittade 4 avhandlingar innehållade ordet Pitx3.

  1. 1. On the influence of dopamine-related genetic variation on dopamine-related disorders

    Författare :Olle Bergman; Göteborgs universitet; []
    Nyckelord :dopamine; neurodevelopment; amygdala; schizophrenia; Parkinson s disease; social anxiety disorder; ADHD; PITX3; LMX1A; LMX1B; BDNF; DAT; SNP; genes; genetics; BDNF;

    Sammanfattning : Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are under the influence of numerous transcription and neurotrophic factors. LÄS MER

  3. 2. Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development

    Författare :Anna Zettergren; Göteborgs universitet; []
    Nyckelord :Parkinson s disease; genetics; inflammation; single nucleotide polymorphism; dopamine neuron development; estrogen; gene; age of onset; Pitx3; estrogen receptor beta; interleukin 6;

    Sammanfattning : Abstract GENETICS OF PARKINSON’S DISEASE - WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be influenced by genetic factors. In some rare cases of familial PD, mutations in some specific genes are known to cause the disease, but in the more common sporadic form of PD the causes are probably environmental factors interacting with genetic vulnerability. LÄS MER

  4. 3. Molecular and cellular characterization of midbrain dopaminergic neuron development

    Författare :Daniel Gyllborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. LÄS MER

  5. 4. Mechanisms controlling midbrain dopaminergic neuron development

    Författare :Shanzheng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. LÄS MER