Sökning: "Paul Ackermann"

Hittade 3 avhandlingar innehållade orden Paul Ackermann.

  1. 1. Peptidergic innervation of periarticular tissue : a study in the rat

    Författare :Paul Ackermann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immunohistochemistry; radioimmunoassay; pain measurement; Achilles tendon; collateral ligaments; joint capsules; tendon rupture; regeneration; peripheral nervous system; neuropeptides; delta opioid receptor;

    Sammanfattning : Painful musculo-skeletal disorders pose a tremendous burden on the healthcare system, the main reason being the limited knowledge of the underlying pathomechanisms and lack of specific treatment. Hypothetically, the peripheral nervous system in the musculo-skeletal tissues plays an important role in the regulation of pain, inflammation, vasoactivity and also tissue repair. LÄS MER

  3. 2. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

    Författare :Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

    Sammanfattning : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. LÄS MER

  4. 3. Influence of neuromodulators and mechanical loading on pathological cell and tissue characteristics in tendinosis

    Författare :Gloria Fong; Patrik Danielson; Alex Scott; Ludvig Backman; Paul Ackermann; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P; acetylcholine; transforming growth factor; neuromodulators; mechanical loading; tendinosis; anatomi; Human Anatomy;

    Sammanfattning : Background: Tendinosis is a painful chronic, degenerative condition characterized by objective changes in the tissue structure of a tendon. Hallmark features in tendinosis tendons include increased number of cells (hypercellularity), extracellular matrix (ECM) degradation and disorganized collagen. LÄS MER