Sökning: "PKCζ"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet PKCζ.
1. Non-canonical TGFb signaling pathways in prostate cancer
Sammanfattning : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. LÄS MER
2. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer
Sammanfattning : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. LÄS MER
3. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells
Sammanfattning : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. LÄS MER
4. RhoGTPase Signaling in Cell Polarity and Gene Regulation
Sammanfattning : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. LÄS MER
5. Functional and genetic studies in type 2 diabetes and obesity
Sammanfattning : Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and mortality. LÄS MER