Sökning: "PIP2"

Hittade 5 avhandlingar innehållade ordet PIP2.

  1. 1. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

    Författare :Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. LÄS MER

  3. 2. Plant major intrinsic proteins - functional implications of expression and localisation studies

    Författare :Laure Fraysse; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant biochemistry; immunolabelling; microarray; plasma membrane; aquaporins; plant; water; Växtbiokemi;

    Sammanfattning : Plant water channels are members of the very old Major Intrinsic Protein (MIP) family, with representatives in bacteria, fungi, animals, and plants. The genome of the model plant Arabidopsis thaliana contains 35 MIP genes. LÄS MER

  4. 3. Expression and Function of Human and Plant Aquaporins

    Författare :Maria Agemark; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquaporin; water channel; overexpression; Pichia pastoris; AQP8; AQP5; SoPIP2; 1;

    Sammanfattning : The aquaporins (AQPs) belong to a family of water permeable membrane channels found in virtually all living organisms. Thirteen isoforms of mammalian AQPs are found, whereas in Arabidopsis thaliana 35 genes encoding AQPs are found. The AQPs are distributed in different organs, cell types and in different subcellular membranes. LÄS MER

  5. 4. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer

    Författare :Martuza Sarwar; Malmö Experimentell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate Cancer; Breast cancer; Cancer therapy; PIP5K1A; PI3K AKT signal pathway; Kinase inhibitors;

    Sammanfattning : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. LÄS MER

  7. 5. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

    Författare :Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. LÄS MER