Sökning: "Olfactory bulb"

Visar resultat 1 - 5 av 56 avhandlingar innehållade orden Olfactory bulb.

  1. 1. Olfactory Transfer of Analgesic Drugs After Nasal Administration

    Författare :Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
    Nyckelord :Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

    Sammanfattning : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. LÄS MER

  3. 2. Computational Modelling of Early Olfactory Processing

    Författare :Malin Sandström; Anders Lansner; Jeanette Hällgren Kotaleski; Thomas Nowotny; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfaction; olfactory system; olfactory bulb; olfactory receptor neuron; synchronization; CaMKII; mathematical modelling; lukt; luktsystemet; luktbulben; synkronisering; CaMKII; matematisk modellering; Computer science; Datavetenskap;

    Sammanfattning : Chemical sensing is believed to be the oldest sensory ability. The chemical senses, olfaction and gustation, developed to detect and analyze information in the form of air- or waterborne chemicals, to find food and mates, and to avoid danger. LÄS MER

  4. 3. Early Information Processing in the Vertebrate Olfactory System : A Computational Study

    Författare :Malin Sandström; Anders Lansner; Dominique Martinez; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfaction; olfactory system; olfactory bulb; synchronisation; CaMKII; mathematical modelling; Computer science; Datavetenskap;

    Sammanfattning : The olfactory system is believed to be the oldest sensory system. It developed to detect and analyse chemical information in the form of odours, and its organisation follows the same principles in almost all living animals - insects as well as mammals. LÄS MER

  5. 4. Machine Learning Techniques with Specific Application to the Early Olfactory System

    Författare :Benjamin Auffarth; Anders Lansner; Tony Lindeberg; Tim Pearce; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; feature selection; image features; pattern classification; relevance; redundancy; distributional similarity; divergence measure; genetic algorithms; clustering algorithms; annealing; olfactory coding; olfactory bulb; odorants; glomeruli; property-activity relationship; olfaction; plasticity; axonal guidance; odor category; perception; spatial coding; population coding; memory organization; odor quality; SRA - ICT; SRA - Informations- och kommunikationsteknik;

    Sammanfattning : This thesis deals with machine learning techniques for the extraction of structure and the analysis of the vertebrate olfactory pathway based on related methods. Some of its main contributions are summarized below. LÄS MER

  7. 5. Nasal administration of compounds active in the central nervous system : Exploring the olfactory system

    Författare :Maria Dahlin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Nasal administration; olfactory pathway; cerebrospinal fluid; autoradiography; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : The nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the nasal mucosa, resulting in a rapid onset of action, and also avoiding degradation in the gastrointestinal tract and first-pass metabolism in the liver. LÄS MER