Sökning: "Olanzapine"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet Olanzapine.

1. 1. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

   Författare :Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. LÄS MER

3. 2. Eating Disorders - Aspects of Treatment and Outcome

   Författare :Agneta Rosling; Ingemar Swenne; Elisabet Wentz; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anorexia Nervosa; Eating Disorders; Mortality; Standard Mortality Ratio; Adolescent; Family-Based Treatment; Out-patient; Olanzapine; Omega-3; Child and Youth Psychiatry; Barn- och ungdomspsykiatri;

   Sammanfattning : Eating disorders (ED) usually develop during adolescence, and intervention to stop further weight loss is believed to improve outcome and long-term prognosis. Adolescents with ED who do not receive effective treatment risk poor outcome and even untimely death as adults. LÄS MER

4. 3. Treatments and outcomes in bipolar disorder

   Författare :Erik Joas; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bipolar disorder; lithium; psychoeducation; CYP2C19; antidepressants; epidemiology; valproate; quetiapine; olanzapine; suicide;

   Sammanfattning : Bipolar disorder is defined by recurring mood episodes and patients have a markedly increased risk of suicide. Pharmacological and psychological treatments for bipolar disorder have proven efficacy in clinical trials yet the generalizability of current evidence to routine clinical practice is contested. LÄS MER

5. 4. Studies on Variability in Olanzapine Disposition

   Författare :Elisabeth Skogh; Staffan Hägg; Marja Liisa Dahl; Markus Heilig; Lena Flyckt; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Schizophrenia and schizoaffective disorders are chronic conditions with a significant impact on many functions. Positive, negative, cognitive and motor symptoms appear in different degrees and constellations. Antipsychotics are of fundamental importance to reduce symptoms. LÄS MER

7. 5. Influence of antipsychotic drugs on hormone levels

   Författare :Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

   Sammanfattning : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. LÄS MER